Main constraints for RNAi induced by expressed long dsRNA in mouse cells.

RNAi is the sequence-specific mRNA degradation guided by siRNAs produced from long dsRNA by RNase Dicer. Proteins executing RNAi are present in mammalian cells but rather sustain the microRNA pathway.

Aiming for a systematic analysis of mammalian RNAi, we report here that the main bottleneck for RNAi efficiency is the production of functional siRNAs, which integrates Dicer activity, dsRNA structure, and siRNA targeting efficiency. Unexpectedly, increased expression of Dicer cofactors TARBP2 or PACT reduces RNAi but not microRNA function.

Elimination of protein kinase R, a key dsRNA sensor in the interferon response, had minimal positive effects on RNAi activity in fibroblasts. Without high Dicer activity, RNAi can still occur when the initial Dicer cleavage of the substrate yields an efficient siRNA.

COVER GLASS, NO. 2, SQUARE 18 X 18MM

2855-18 50/pk
EUR 83
Description: Cover Glass; Cover Glass, CGW

Bovine Serum Amyloid A (SAA) ELISA Kit

RD-SAA-b-48Tests 48 Tests
EUR 555

Bovine Serum Amyloid A (SAA) ELISA Kit

RD-SAA-b-96Tests 96 Tests
EUR 771

Human Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Hu-48Tests 48 Tests
EUR 478

Human Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Hu-96Tests 96 Tests
EUR 662

Mouse Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Mu-48Tests 48 Tests
EUR 489

Mouse Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Mu-96Tests 96 Tests
EUR 677

Rabbit Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Rb-48Tests 48 Tests
EUR 511

Rabbit Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Rb-96Tests 96 Tests
EUR 709

Bovine Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-b-48T 48T
EUR 547
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids.

Bovine Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-b-96T 96T
EUR 715
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids.

Human Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Hu-48T 48T
EUR 479
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Hu-96T 96T
EUR 621
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Mu-48T 48T
EUR 489
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Mu-96T 96T
EUR 635
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Rb-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Rb-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-b-48Tests 48 Tests
EUR 580

Bovine Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-b-96Tests 96 Tests
EUR 807

Human Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Hu-48Tests 48 Tests
EUR 500

Human Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Hu-96Tests 96 Tests
EUR 692

Mouse Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Mu-48Tests 48 Tests
EUR 511

Mouse Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Mu-96Tests 96 Tests
EUR 709

Rabbit Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Rb-48Tests 48 Tests
EUR 534

Rabbit Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Rb-96Tests 96 Tests
EUR 742

COVER GLASS, NO. 1 1/2, SQUARE 18 X 18MM

2850-18 100/pk
EUR 131
Description: Cover Glass; Cover Glass, CGW

TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 10 tests/pack

SAA-RDT-10 1 pack
EUR 171

TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 25 tests/pack

SAA-RDT-25 1 pack
EUR 293

SAA-PEG-SAA

abx085047-20kDa1g 20 kDa; 1 g
EUR 453

SAA-PEG-SAA

abx085047-2kDa1g 2 kDa; 1 g
EUR 453

SAA-PEG-SAA

abx085047-10kDa1g 10 kDa; 1 g
EUR 453

SAA-PEG-SAA

abx085047-1kDa1g 1 kDa; 1 g
EUR 453

SAA-PEG-SAA,10K

33-HO015015-10K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,1K

33-HO015015-1K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,20K

33-HO015015-20K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,2K

33-HO015015-2K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,3.4K

33-HO015015-3.4K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,5K

33-HO015015-5K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA

E64C01201 20ug
EUR 382

FT4 (Free thyroxine) ELISA test

18 96T/Box Ask for price
Description: ELISA based test for quantitative detection of FT4 (Free thyroxine)

SAA Protein

abx060299-100ug 100 ug
EUR 829

mPEG-SAA

abx085023-10kDa1g 10 kDa; 1 g
EUR 370

mPEG-SAA

abx085023-1kDa1g 1 kDa; 1 g
EUR 356

mPEG-SAA

abx085023-20kDa1g 20 kDa; 1 g
EUR 370

mPEG-SAA

abx085023-2kDa1g 2 kDa; 1 g
EUR 356

mPEG-SAA

abx085023-5kDa1g 5 kDa; 1 g
EUR 356

Bovine(SAA)

QY-E60061 96T
EUR 426

SAA antibody

10-7959 500 ug
EUR 349
Description: Mouse monoclonal SAA antibody

SAA antibody

10-7960 500 ug
EUR 349
Description: Mouse monoclonal SAA antibody

SAA antibody

10R-10351 100 ug
EUR 435
Description: Mouse monoclonal SAA antibody

SAA antibody

20-1715 1 ml
EUR 138
Description: Goat polyclonal SAA antibody

mPEG-SAA,10K

33-MF001015-10K
  • EUR 211.00
  • EUR 531.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,1K

33-MF001015-1K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,20K

33-MF001015-20K
  • EUR 211.00
  • EUR 531.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,2K

33-MF001015-2K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,30K

33-MF001015-30K
  • EUR 211.00
  • EUR 531.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,4K

33-MF001015-4K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,5K

33-MF001015-5K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Recombinant Human SAA

P0209 100ug
EUR 522.36
Description: Recombinant Human protein for SAA

Apo SAA antibody

20R-1792 100 ug
EUR 673
Description: Rabbit polyclonal Apo SAA antibody

Sheep SAA ELISA Kit

ESS0235 96Tests
EUR 521

Human SAA ELISA Kit

DEIA450 96T
EUR 1060
Description: ThisHuman SAA ELISA Kit is to be used for the in vitro quantitative determinationof human serum amyloid A (SAA) concentrations in serum, plasma, cell culture supernatant, and other biological fluids.

Rat SAA ELISA Kit

ERS0235 96Tests
EUR 521

Rabbit SAA ELISA Kit

ERTS0235 96Tests
EUR 521

Monkey SAA ELISA Kit

EMKS0235 96Tests
EUR 521

Mouse SAA ELISA Kit

EMS0235 96Tests
EUR 521

Porcine SAA ELISA Kit

EPS0235 96Tests
EUR 521

Goat SAA ELISA Kit

EGTS0235 96Tests
EUR 521

Human SAA ELISA Kit

EHS0235 96Tests
EUR 521

Bovine SAA ELISA Kit

EBS0235 96Tests
EUR 521

Chicken SAA ELISA Kit

ECKS0235 96Tests
EUR 521

Canine SAA ELISA Kit

ECS0235 96Tests
EUR 521

Anserini SAA ELISA Kit

EAS0235 96Tests
EUR 521

4-ArmPEG-SAA,10K

33-A44015-10K
  • EUR 174.00
  • EUR 420.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-ArmPEG-SAA,20K

33-A44015-20K
  • EUR 174.00
  • EUR 420.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-ArmPEG-SAA,2K

33-A44015-2K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,10K

33-A88015-10K
  • EUR 149.00
  • EUR 346.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,20K

33-A88015-20K
  • EUR 149.00
  • EUR 346.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,40K

33-A88015-40K
  • EUR 174.00
  • EUR 420.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-Arm PEG-SAA

abx085101-10kDa1g 10 kDa; 1 g
EUR 384

4-Arm PEG-SAA

abx085101-10kDa5g 10 kDa; 5 g
EUR 634

4-Arm PEG-SAA

abx085101-20kDa5g 20 kDa; 5 g
EUR 634

4-Arm PEG-SAA

abx085101-2kDa1g 2 kDa; 1 g
EUR 356

8-Arm PEG-SAA

abx085112-10kDa1g 10 kDa; 1 g
EUR 328

8-Arm PEG-SAA

abx085112-10kDa5g 10 kDa; 5 g
EUR 620

8-Arm PEG-SAA

abx085112-20kDa5g 20 kDa; 5 g
EUR 620

8-Arm PEG-SAA

abx085112-40kDa1g 40 kDa; 1 g
EUR 356

SAA ELISA KIT|Human

EF000259 96 Tests
EUR 689

Apo-SAA, human recombinant

4324-10
EUR 137

Apo-SAA, human recombinant

4324-1000
EUR 920

Apo-SAA, human recombinant

4324-50
EUR 256

Apo-SAA, human recombinant

4324-500
EUR 756

Cat SAA ELISA Kit

E-20SAA 1 x 96 well plate
EUR 461

Chicken SAA ELISA Kit

E-30SAA 1 x 96 well plate
EUR 492

Dog SAA ELISA Kit

E-40SAA 1 x 96 well plate
EUR 461

Horse SAA ELISA Kit

E-70SAA 1 x 96 well plate
EUR 517

Efficient mammalian RNAi may use substrates with some features of microRNA precursors, merging both pathways even more than previously suggested. Although optimized endogenous Dicer substrates mimicking miRNA features could evolve for endogenous regulations, the same principles would make antiviral RNAi inefficient as viruses would adapt to avoid efficacy.