Main constraints for RNAi induced by expressed long dsRNA in mouse cells.

RNAi is the sequence-specific mRNA degradation guided by siRNAs produced from long dsRNA by RNase Dicer. Proteins executing RNAi are present in mammalian cells but rather sustain the microRNA pathway.

Aiming for a systematic analysis of mammalian RNAi, we report here that the main bottleneck for RNAi efficiency is the production of functional siRNAs, which integrates Dicer activity, dsRNA structure, and siRNA targeting efficiency. Unexpectedly, increased expression of Dicer cofactors TARBP2 or PACT reduces RNAi but not microRNA function.

Elimination of protein kinase R, a key dsRNA sensor in the interferon response, had minimal positive effects on RNAi activity in fibroblasts. Without high Dicer activity, RNAi can still occur when the initial Dicer cleavage of the substrate yields an efficient siRNA.

COVER GLASS, NO. 2, SQUARE 18 X 18MM
2855-18	CORNING	50/pk	EUR 83
Description: Cover Glass; Cover Glass, CGW

Bovine Serum Amyloid A (SAA) ELISA Kit
RD-SAA-b-48Tests	Reddot Biotech	48 Tests	EUR 555

Bovine Serum Amyloid A (SAA) ELISA Kit
RD-SAA-b-96Tests	Reddot Biotech	96 Tests	EUR 771

Human Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Hu-48Tests	Reddot Biotech	48 Tests	EUR 478

Human Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Hu-96Tests	Reddot Biotech	96 Tests	EUR 662

Mouse Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Mu-48Tests	Reddot Biotech	48 Tests	EUR 489

Mouse Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Mu-96Tests	Reddot Biotech	96 Tests	EUR 677

Rabbit Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Rb-48Tests	Reddot Biotech	48 Tests	EUR 511

Rabbit Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Rb-96Tests	Reddot Biotech	96 Tests	EUR 709

Bovine Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-b-48T	DL Develop	48T	EUR 547
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids.

Bovine Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-b-96T	DL Develop	96T	EUR 715
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids.

Human Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Hu-48T	DL Develop	48T	EUR 479
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Hu-96T	DL Develop	96T	EUR 621
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Mu-48T	DL Develop	48T	EUR 489
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Mu-96T	DL Develop	96T	EUR 635
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Rb-48T	DL Develop	48T	EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Rb-96T	DL Develop	96T	EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-b-48Tests	Reddot Biotech	48 Tests	EUR 580

Bovine Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-b-96Tests	Reddot Biotech	96 Tests	EUR 807

Human Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Hu-48Tests	Reddot Biotech	48 Tests	EUR 500

Human Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Hu-96Tests	Reddot Biotech	96 Tests	EUR 692

Mouse Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Mu-48Tests	Reddot Biotech	48 Tests	EUR 511

Mouse Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Mu-96Tests	Reddot Biotech	96 Tests	EUR 709

Rabbit Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Rb-48Tests	Reddot Biotech	48 Tests	EUR 534

Rabbit Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Rb-96Tests	Reddot Biotech	96 Tests	EUR 742

COVER GLASS, NO. 1 1/2, SQUARE 18 X 18MM
2850-18	CORNING	100/pk	EUR 131
Description: Cover Glass; Cover Glass, CGW

TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 10 tests/pack
SAA-RDT-10	Alpha Diagnostics	1 pack	EUR 171

TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 25 tests/pack
SAA-RDT-25	Alpha Diagnostics	1 pack	EUR 293

SAA-PEG-SAA
abx085047-20kDa1g	Abbexa	20 kDa; 1 g	EUR 453

SAA-PEG-SAA
abx085047-2kDa1g	Abbexa	2 kDa; 1 g	EUR 453

SAA-PEG-SAA
abx085047-10kDa1g	Abbexa	10 kDa; 1 g	EUR 453

SAA-PEG-SAA
abx085047-1kDa1g	Abbexa	1 kDa; 1 g	EUR 453

SAA-PEG-SAA,10K
33-HO015015-10K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,1K
33-HO015015-1K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,20K
33-HO015015-20K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,2K
33-HO015015-2K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,3.4K
33-HO015015-3.4K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,5K
33-HO015015-5K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA
E64C01201	EnoGene	20ug	EUR 382

FT4 (Free thyroxine) ELISA test
18	Biobase	96T/Box	Ask for price
Description: ELISA based test for quantitative detection of FT4 (Free thyroxine)

SAA Protein
abx060299-100ug	Abbexa	100 ug	EUR 829

mPEG-SAA
abx085023-10kDa1g	Abbexa	10 kDa; 1 g	EUR 370

mPEG-SAA
abx085023-1kDa1g	Abbexa	1 kDa; 1 g	EUR 356

mPEG-SAA
abx085023-20kDa1g	Abbexa	20 kDa; 1 g	EUR 370

mPEG-SAA
abx085023-2kDa1g	Abbexa	2 kDa; 1 g	EUR 356

mPEG-SAA
abx085023-5kDa1g	Abbexa	5 kDa; 1 g	EUR 356

Bovine(SAA)
QY-E60061	Qayee Biotechnology	96T	EUR 426

SAA antibody
10-7959	Fitzgerald	500 ug	EUR 349
Description: Mouse monoclonal SAA antibody

SAA antibody
10-7960	Fitzgerald	500 ug	EUR 349
Description: Mouse monoclonal SAA antibody

SAA antibody
10R-10351	Fitzgerald	100 ug	EUR 435
Description: Mouse monoclonal SAA antibody

SAA antibody
20-1715	Fitzgerald	1 ml	EUR 138
Description: Goat polyclonal SAA antibody

mPEG-SAA,10K
33-MF001015-10K	Biochempeg	EUR 211.00 EUR 531.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,1K
33-MF001015-1K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,20K
33-MF001015-20K	Biochempeg	EUR 211.00 EUR 531.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,2K
33-MF001015-2K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,30K
33-MF001015-30K	Biochempeg	EUR 211.00 EUR 531.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,4K
33-MF001015-4K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,5K
33-MF001015-5K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Recombinant Human SAA
P0209	FN Test	100ug	EUR 522.36
Description: Recombinant Human protein for SAA

Apo SAA antibody
20R-1792	Fitzgerald	100 ug	EUR 673
Description: Rabbit polyclonal Apo SAA antibody

Sheep SAA ELISA Kit
ESS0235	Abclonal	96Tests	EUR 521

Human SAA ELISA Kit
DEIA450	Creative Diagnostics	96T	EUR 1060
Description: ThisHuman SAA ELISA Kit is to be used for the in vitro quantitative determinationof human serum amyloid A (SAA) concentrations in serum, plasma, cell culture supernatant, and other biological fluids.

Rat SAA ELISA Kit
ERS0235	Abclonal	96Tests	EUR 521

Rabbit SAA ELISA Kit
ERTS0235	Abclonal	96Tests	EUR 521

Monkey SAA ELISA Kit
EMKS0235	Abclonal	96Tests	EUR 521

Mouse SAA ELISA Kit
EMS0235	Abclonal	96Tests	EUR 521

Porcine SAA ELISA Kit
EPS0235	Abclonal	96Tests	EUR 521

Goat SAA ELISA Kit
EGTS0235	Abclonal	96Tests	EUR 521

Human SAA ELISA Kit
EHS0235	Abclonal	96Tests	EUR 521

Bovine SAA ELISA Kit
EBS0235	Abclonal	96Tests	EUR 521

Chicken SAA ELISA Kit
ECKS0235	Abclonal	96Tests	EUR 521

Canine SAA ELISA Kit
ECS0235	Abclonal	96Tests	EUR 521

Anserini SAA ELISA Kit
EAS0235	Abclonal	96Tests	EUR 521

4-ArmPEG-SAA,10K
33-A44015-10K	Biochempeg	EUR 174.00 EUR 420.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-ArmPEG-SAA,20K
33-A44015-20K	Biochempeg	EUR 174.00 EUR 420.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-ArmPEG-SAA,2K
33-A44015-2K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,10K
33-A88015-10K	Biochempeg	EUR 149.00 EUR 346.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,20K
33-A88015-20K	Biochempeg	EUR 149.00 EUR 346.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,40K
33-A88015-40K	Biochempeg	EUR 174.00 EUR 420.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-Arm PEG-SAA
abx085101-10kDa1g	Abbexa	10 kDa; 1 g	EUR 384

4-Arm PEG-SAA
abx085101-10kDa5g	Abbexa	10 kDa; 5 g	EUR 634

4-Arm PEG-SAA
abx085101-20kDa5g	Abbexa	20 kDa; 5 g	EUR 634

4-Arm PEG-SAA
abx085101-2kDa1g	Abbexa	2 kDa; 1 g	EUR 356

8-Arm PEG-SAA
abx085112-10kDa1g	Abbexa	10 kDa; 1 g	EUR 328

8-Arm PEG-SAA
abx085112-10kDa5g	Abbexa	10 kDa; 5 g	EUR 620

8-Arm PEG-SAA
abx085112-20kDa5g	Abbexa	20 kDa; 5 g	EUR 620

8-Arm PEG-SAA
abx085112-40kDa1g	Abbexa	40 kDa; 1 g	EUR 356

SAA ELISA KIT|Human
EF000259	Lifescience Market	96 Tests	EUR 689

Apo-SAA, human recombinant
4324-10	Biovision		EUR 137

Apo-SAA, human recombinant
4324-1000	Biovision		EUR 920

Apo-SAA, human recombinant
4324-50	Biovision		EUR 256

Apo-SAA, human recombinant
4324-500	Biovision		EUR 756

Cat SAA ELISA Kit
E-20SAA	Immunology Consultants Laboratory	1 x 96 well plate	EUR 461

Chicken SAA ELISA Kit
E-30SAA	Immunology Consultants Laboratory	1 x 96 well plate	EUR 492

Dog SAA ELISA Kit
E-40SAA	Immunology Consultants Laboratory	1 x 96 well plate	EUR 461

Horse SAA ELISA Kit
E-70SAA	Immunology Consultants Laboratory	1 x 96 well plate	EUR 517

Efficient mammalian RNAi may use substrates with some features of microRNA precursors, merging both pathways even more than previously suggested. Although optimized endogenous Dicer substrates mimicking miRNA features could evolve for endogenous regulations, the same principles would make antiviral RNAi inefficient as viruses would adapt to avoid efficacy.