Main constraints for RNAi induced by expressed long dsRNA in mouse cells.

RNAi is the sequence-specific mRNA degradation guided by siRNAs produced from long dsRNA by RNase Dicer. Proteins executing RNAi are present in mammalian cells but rather sustain the microRNA pathway.

Aiming for a systematic analysis of mammalian RNAi, we report here that the main bottleneck for RNAi efficiency is the production of functional siRNAs, which integrates Dicer activity, dsRNA structure, and siRNA targeting efficiency. Unexpectedly, increased expression of Dicer cofactors TARBP2 or PACT reduces RNAi but not microRNA function.

Elimination of protein kinase R, a key dsRNA sensor in the interferon response, had minimal positive effects on RNAi activity in fibroblasts. Without high Dicer activity, RNAi can still occur when the initial Dicer cleavage of the substrate yields an efficient siRNA.

9998 SCREW CAP 415/18
9998-18	CORNING	192/pk	EUR 103.00
Description: General Apparatus; Stoppers

COVER GLASS, NO. 2, SQUARE 18 X 18MM
2855-18	CORNING	50/pk	EUR 83.00
Description: Cover Glass; Cover Glass, CGW

COVER GLASS, NO. 1, SQUARE 18 X 18MM
2845-18	CORNING	100/pk	EUR 112.00
Description: Cover Glass; Cover Glass, CGW

Bovine Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-b-48T	DL Develop	48T	EUR 547.00
Should the Bovine Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids.

Bovine Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-b-96T	DL Develop	96T	EUR 715.00
Should the Bovine Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids.

Human Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Hu-48T	DL Develop	48T	EUR 479.00
Should the Human Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Hu-96T	DL Develop	96T	EUR 621.00
Should the Human Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Mu-48T	DL Develop	48T	EUR 489.00
Should the Mouse Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Mu-96T	DL Develop	96T	EUR 635.00
Should the Mouse Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Rb-48T	DL Develop	48T	EUR 508.00
Should the Rabbit Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Rb-96T	DL Develop	96T	EUR 661.00
Should the Rabbit Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Serum Amyloid A (SAA) ELISA Kit
DL-SAA-b-192	DLdevelop	1 kit of 192 tests	EUR 1231.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Bovine Serum Amyloid A (SAA)

Bovine Serum Amyloid A (SAA) ELISA Kit
DL-SAA-b-48	DLdevelop	1 kit of 48 tests	EUR 510.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Bovine Serum Amyloid A (SAA)

Bovine Serum Amyloid A (SAA) ELISA Kit
DL-SAA-b-96	DLdevelop	1 kit of 96 tests	EUR 685.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Bovine Serum Amyloid A (SAA)

Human Serum Amyloid A (SAA) ELISA Kit
DL-SAA-Hu-192	DLdevelop	1 kit of 192 tests	EUR 1054.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Human Serum Amyloid A (SAA)

Human Serum Amyloid A (SAA) ELISA Kit
DL-SAA-Hu-48	DLdevelop	1 kit of 48 tests	EUR 447.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Human Serum Amyloid A (SAA)

Human Serum Amyloid A (SAA) ELISA Kit
DL-SAA-Hu-96	DLdevelop	1 kit of 96 tests	EUR 597.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Human Serum Amyloid A (SAA)

Mouse Serum Amyloid A (SAA) ELISA Kit
DL-SAA-Mu-192	DLdevelop	1 kit of 192 tests	EUR 1079.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Mouse Serum Amyloid A (SAA)

Mouse Serum Amyloid A (SAA) ELISA Kit
DL-SAA-Mu-48	DLdevelop	1 kit of 48 tests	EUR 456.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Mouse Serum Amyloid A (SAA)

Mouse Serum Amyloid A (SAA) ELISA Kit
DL-SAA-Mu-96	DLdevelop	1 kit of 96 tests	EUR 609.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Mouse Serum Amyloid A (SAA)

Rabbit Serum Amyloid A (SAA) ELISA Kit
DL-SAA-Rb-192	DLdevelop	1 kit of 192 tests	EUR 1130.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Rabbit Serum Amyloid A (SAA)

Rabbit Serum Amyloid A (SAA) ELISA Kit
DL-SAA-Rb-48	DLdevelop	1 kit of 48 tests	EUR 474.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Rabbit Serum Amyloid A (SAA)

Rabbit Serum Amyloid A (SAA) ELISA Kit
DL-SAA-Rb-96	DLdevelop	1 kit of 96 tests	EUR 635.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Rabbit Serum Amyloid A (SAA)

Bovine Serum Amyloid A (SAA) ELISA Kit
RD-SAA-b-48Tests	Reddot Biotech	48 Tests	EUR 555.00

Bovine Serum Amyloid A (SAA) ELISA Kit
RD-SAA-b-96Tests	Reddot Biotech	96 Tests	EUR 771.00

Human Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Hu-48Tests	Reddot Biotech	48 Tests	EUR 478.00

Human Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Hu-96Tests	Reddot Biotech	96 Tests	EUR 662.00

Mouse Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Mu-48Tests	Reddot Biotech	48 Tests	EUR 489.00

Mouse Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Mu-96Tests	Reddot Biotech	96 Tests	EUR 677.00

Rabbit Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Rb-48Tests	Reddot Biotech	48 Tests	EUR 511.00

Rabbit Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Rb-96Tests	Reddot Biotech	96 Tests	EUR 709.00

Bovine Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-b-48Tests	Reddot Biotech	48 Tests	EUR 580.00

Bovine Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-b-96Tests	Reddot Biotech	96 Tests	EUR 807.00

Human Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Hu-48Tests	Reddot Biotech	48 Tests	EUR 500.00

Human Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Hu-96Tests	Reddot Biotech	96 Tests	EUR 692.00

Mouse Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Mu-48Tests	Reddot Biotech	48 Tests	EUR 511.00

Mouse Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Mu-96Tests	Reddot Biotech	96 Tests	EUR 709.00

Rabbit Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Rb-48Tests	Reddot Biotech	48 Tests	EUR 534.00

Rabbit Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Rb-96Tests	Reddot Biotech	96 Tests	EUR 742.00

COVER GLASS, NO. 1 1/2, SQUARE 18 X 18MM
2850-18	CORNING	100/pk	EUR 131.00
Description: Cover Glass; Cover Glass, CGW

TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 10 tests/pack
SAA-RDT-10	Alpha Diagnostics	1 pack	EUR 171.00

TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 25 tests/pack
SAA-RDT-25	Alpha Diagnostics	1 pack	EUR 293.00

SAA-PEG-SAA
abx085047-10kDa1g	Abbexa	10 kDa; 1 g	EUR 453.00
Shipped within 5-10 working days.

SAA-PEG-SAA
abx085047-1kDa1g	Abbexa	1 kDa; 1 g	EUR 453.00
Shipped within 5-10 working days.

SAA-PEG-SAA
abx085047-20kDa1g	Abbexa	20 kDa; 1 g	EUR 453.00
Shipped within 5-10 working days.

SAA-PEG-SAA
abx085047-2kDa1g	Abbexa	2 kDa; 1 g	EUR 453.00
Shipped within 5-10 working days.

SAA-PEG-SAA,10K
33-HO015015-10K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,1K
33-HO015015-1K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,20K
33-HO015015-20K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,2K
33-HO015015-2K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,3.4K
33-HO015015-3.4K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,5K
33-HO015015-5K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA
E64C01201	EnoGene	20ug	EUR 382.00

FT4 (Free thyroxine) ELISA test
18	Biobase	96T/Box	Ask for price
Area of application: Hormone testing
Description: ELISA based test for quantitative detection of FT4 (Free thyroxine)

mPEG-SAA
abx085023-10kDa1g	Abbexa	10 kDa; 1 g	EUR 370.00
Shipped within 5-10 working days.

mPEG-SAA
abx085023-1kDa1g	Abbexa	1 kDa; 1 g	EUR 356.00
Shipped within 5-10 working days.

mPEG-SAA
abx085023-20kDa1g	Abbexa	20 kDa; 1 g	EUR 370.00
Shipped within 5-10 working days.

mPEG-SAA
abx085023-2kDa1g	Abbexa	2 kDa; 1 g	EUR 356.00
Shipped within 5-10 working days.

mPEG-SAA
abx085023-5kDa1g	Abbexa	5 kDa; 1 g	EUR 356.00
Shipped within 5-10 working days.

SAA antibody
20-1715	Fitzgerald	1 ml	EUR 138.00
Description: Goat polyclonal SAA antibody

SAA antibody
10R-10351	Fitzgerald	100 ug	EUR 435.00
Description: Mouse monoclonal SAA antibody

SAA antibody
10-7959	Fitzgerald	500 ug	EUR 349.00
Description: Mouse monoclonal SAA antibody

SAA antibody
10-7960	Fitzgerald	500 ug	EUR 349.00
Description: Mouse monoclonal SAA antibody

SAA Protein
abx060299-100ug	Abbexa	100 ug	EUR 829.00
Shipped within 5-10 working days.

Bovine(SAA)
QY-E60061	Qayee Biotechnology	96T	EUR 426.00

Apo SAA antibody
20R-1792	Fitzgerald	100 ug	EUR 673.00
Description: Rabbit polyclonal Apo SAA antibody

mPEG-SAA,10K
33-MF001015-10K	Biochempeg	EUR 211.00 EUR 531.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,1K
33-MF001015-1K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,20K
33-MF001015-20K	Biochempeg	EUR 211.00 EUR 531.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,2K
33-MF001015-2K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,30K
33-MF001015-30K	Biochempeg	EUR 211.00 EUR 531.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,4K
33-MF001015-4K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,5K
33-MF001015-5K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Recombinant Human SAA
P0209	FN Test	100ug	EUR 522.36
Formulation: pH7.4, Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose Reconstitution: Sterile distilled water Purity: Greater than 95% by SDS-PAGE gel analyses Uniprot ID: P0DJI8
Description: Recombinant Human protein for SAA

4-Arm PEG-SAA
abx085101-10kDa1g	Abbexa	10 kDa; 1 g	EUR 384.00
Shipped within 5-10 working days.

4-Arm PEG-SAA
abx085101-10kDa5g	Abbexa	10 kDa; 5 g	EUR 634.00
Shipped within 5-10 working days.

4-Arm PEG-SAA
abx085101-20kDa5g	Abbexa	20 kDa; 5 g	EUR 634.00
Shipped within 5-10 working days.

4-Arm PEG-SAA
abx085101-2kDa1g	Abbexa	2 kDa; 1 g	EUR 356.00
Shipped within 5-10 working days.

8-Arm PEG-SAA
abx085112-10kDa1g	Abbexa	10 kDa; 1 g	EUR 328.00
Shipped within 5-10 working days.

8-Arm PEG-SAA
abx085112-10kDa5g	Abbexa	10 kDa; 5 g	EUR 620.00
Shipped within 5-10 working days.

8-Arm PEG-SAA
abx085112-20kDa5g	Abbexa	20 kDa; 5 g	EUR 620.00
Shipped within 5-10 working days.

8-Arm PEG-SAA
abx085112-40kDa1g	Abbexa	40 kDa; 1 g	EUR 356.00
Shipped within 5-10 working days.

Apo-SAA, human recombinant
4324-10	Biovision		EUR 137.00

Apo-SAA, human recombinant
4324-1000	Biovision		EUR 920.00

Apo-SAA, human recombinant
4324-50	Biovision		EUR 256.00

Apo-SAA, human recombinant
4324-500	Biovision		EUR 756.00

4-ArmPEG-SAA,10K
33-A44015-10K	Biochempeg	EUR 174.00 EUR 420.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-ArmPEG-SAA,20K
33-A44015-20K	Biochempeg	EUR 174.00 EUR 420.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-ArmPEG-SAA,2K
33-A44015-2K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Cat SAA ELISA Kit
E-20SAA	ICL lab	1 x 96 well plate	EUR 461.00

Chicken SAA ELISA Kit
E-30SAA	ICL lab	1 x 96 well plate	EUR 492.00

Dog SAA ELISA Kit
E-40SAA	ICL lab	1 x 96 well plate	EUR 461.00

Horse SAA ELISA Kit
E-70SAA	ICL lab	1 x 96 well plate	EUR 517.00

Human SAA ELISA Kit
E-80SAA	ICL lab	1 x 96 well plate	EUR 461.00

Mouse SAA ELISA Kit
E-90SAA	ICL lab	1 x 96 well plate	EUR 395.00

8-ArmPEG-SAA,10K
33-A88015-10K	Biochempeg	EUR 149.00 EUR 346.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,20K
33-A88015-20K	Biochempeg	EUR 149.00 EUR 346.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,40K
33-A88015-40K	Biochempeg	EUR 174.00 EUR 420.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Human SAA ELISA Kit
DEIA450	Creative Diagnostics	96T	EUR 1060.00
Description: ThisHuman SAA ELISA Kit is to be used for the in vitro quantitative determinationof human serum amyloid A (SAA) concentrations in serum, plasma, cell culture supernatant, and other biological fluids.

Sheep SAA ELISA Kit
ESS0235	Abclonal	96Tests	EUR 521.00

Porcine SAA ELISA Kit
EPS0235	Abclonal	96Tests	EUR 521.00

Rat SAA ELISA Kit
ERS0235	Abclonal	96Tests	EUR 521.00

Rabbit SAA ELISA Kit
ERTS0235	Abclonal	96Tests	EUR 521.00

Monkey SAA ELISA Kit
EMKS0235	Abclonal	96Tests	EUR 521.00

Mouse SAA ELISA Kit
EMS0235	Abclonal	96Tests	EUR 521.00

Goat SAA ELISA Kit
EGTS0235	Abclonal	96Tests	EUR 521.00

Anserini SAA ELISA Kit
EAS0235	Abclonal	96Tests	EUR 521.00

Bovine SAA ELISA Kit
EBS0235	Abclonal	96Tests	EUR 521.00

Human SAA ELISA Kit
EHS0235	Abclonal	96Tests	EUR 521.00

Chicken SAA ELISA Kit
ECKS0235	Abclonal	96Tests	EUR 521.00

Efficient mammalian RNAi may use substrates with some features of microRNA precursors, merging both pathways even more than previously suggested. Although optimized endogenous Dicer substrates mimicking miRNA features could evolve for endogenous regulations, the same principles would make antiviral RNAi inefficient as viruses would adapt to avoid efficacy.