Ras and exosome signaling.

Ras gene (HRAS, NRAS, and KRAS) has been observed to be mutated and hyper-activated in a significant proportion of cancers. However, mutant Ras remains a challenging therapeutic target. Similarly, inhibition of targets upstream and downstream of Ras has shown limited clinical utility.

There have been attempts to develop and deliver mutant K-Ras silencing RNAs either through their encapsulation in liposomes or nanoparticles. However, these approaches show very limited success due to the lack of stability of such carrier molecules alongside associated toxicity.

There is a pressing need for the identification of better therapeutic targets for Ras or its associated pathways as well as improvements in the design of superior RNAi delivery systems to suppress mutant K-Ras. More than a decade ago, it was shown that aggregates of palmitoylated Ras isoforms (H-Ras and N-Ras) passage through the cytosol on rapidly moving nanosized particles (“rasosomes”). Fast forward a decade, considerable new knowledge has emerged in the area of small vesicles, microparticles, and exosomes. Exosomes are tiny vesicles and play a significant role in regulating cancer-related signaling pathways.

Human Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Hu-48T	DL Develop	48T	EUR 479
Should the Human Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Hu-96T	DL Develop	96T	EUR 621
Should the Human Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Mu-48T	DL Develop	48T	EUR 489
Should the Mouse Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Mu-96T	DL Develop	96T	EUR 635
Should the Mouse Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Rb-48T	DL Develop	48T	EUR 508
Should the Rabbit Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Serum Amyloid A (SAA) ELISA Kit
DLR-SAA-Rb-96T	DL Develop	96T	EUR 661
Should the Rabbit Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-b-48Tests	Reddot Biotech	48 Tests	EUR 580

Bovine Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-b-96Tests	Reddot Biotech	96 Tests	EUR 807

Human Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Hu-48Tests	Reddot Biotech	48 Tests	EUR 500

Human Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Hu-96Tests	Reddot Biotech	96 Tests	EUR 692

Mouse Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Mu-48Tests	Reddot Biotech	48 Tests	EUR 511

Mouse Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Mu-96Tests	Reddot Biotech	96 Tests	EUR 709

Rabbit Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Rb-48Tests	Reddot Biotech	48 Tests	EUR 534

Rabbit Serum Amyloid A (SAA) ELISA Kit
RDR-SAA-Rb-96Tests	Reddot Biotech	96 Tests	EUR 742

Bovine Serum Amyloid A (SAA) ELISA Kit
RD-SAA-b-48Tests	Reddot Biotech	48 Tests	EUR 555

Bovine Serum Amyloid A (SAA) ELISA Kit
RD-SAA-b-96Tests	Reddot Biotech	96 Tests	EUR 771

Human Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Hu-48Tests	Reddot Biotech	48 Tests	EUR 478

Human Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Hu-96Tests	Reddot Biotech	96 Tests	EUR 662

Mouse Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Mu-48Tests	Reddot Biotech	48 Tests	EUR 489

Mouse Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Mu-96Tests	Reddot Biotech	96 Tests	EUR 677

Rabbit Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Rb-48Tests	Reddot Biotech	48 Tests	EUR 511

Rabbit Serum Amyloid A (SAA) ELISA Kit
RD-SAA-Rb-96Tests	Reddot Biotech	96 Tests	EUR 709

TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 10 tests/pack
SAA-RDT-10	Alpha Diagnostics	1 pack	EUR 171

TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 25 tests/pack
SAA-RDT-25	Alpha Diagnostics	1 pack	EUR 293

SAA-PEG-SAA
abx085047-10kDa1g	Abbexa	10 kDa; 1 g	EUR 453
Shipped within 5-10 working days.

SAA-PEG-SAA
abx085047-1kDa1g	Abbexa	1 kDa; 1 g	EUR 453
Shipped within 5-10 working days.

SAA-PEG-SAA
abx085047-20kDa1g	Abbexa	20 kDa; 1 g	EUR 453
Shipped within 5-10 working days.

SAA-PEG-SAA
abx085047-2kDa1g	Abbexa	2 kDa; 1 g	EUR 453
Shipped within 5-10 working days.

SAA-PEG-SAA,10K
33-HO015015-10K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,1K
33-HO015015-1K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,20K
33-HO015015-20K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,2K
33-HO015015-2K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,3.4K
33-HO015015-3.4K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,5K
33-HO015015-5K	Biochempeg	EUR 259.00 EUR 677.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA
E64C01201	EnoGene	20ug	EUR 382

TESTO (Testosterone) ELISA test
19	Biobase	96T/Box	Ask for price
Area of application: Hormone testing
Description: ELISA based test for quantitative detection of O (osterone)

SAA antibody
10R-10351	Fitzgerald	100 ug	EUR 435
Description: Mouse monoclonal SAA antibody

SAA antibody
10-7959	Fitzgerald	500 ug	EUR 349
Description: Mouse monoclonal SAA antibody

SAA antibody
10-7960	Fitzgerald	500 ug	EUR 349
Description: Mouse monoclonal SAA antibody

SAA antibody
20-1715	Fitzgerald	1 ml	EUR 138
Description: Goat polyclonal SAA antibody

SAA Protein
abx060299-100ug	Abbexa	100 ug	EUR 829
Shipped within 5-10 working days.

mPEG-SAA
abx085023-10kDa1g	Abbexa	10 kDa; 1 g	EUR 370
Shipped within 5-10 working days.

mPEG-SAA
abx085023-1kDa1g	Abbexa	1 kDa; 1 g	EUR 356
Shipped within 5-10 working days.

mPEG-SAA
abx085023-20kDa1g	Abbexa	20 kDa; 1 g	EUR 370
Shipped within 5-10 working days.

mPEG-SAA
abx085023-2kDa1g	Abbexa	2 kDa; 1 g	EUR 356
Shipped within 5-10 working days.

mPEG-SAA
abx085023-5kDa1g	Abbexa	5 kDa; 1 g	EUR 356
Shipped within 5-10 working days.

Bovine(SAA)
QY-E60061	Qayee Biotechnology	96T	EUR 426

Apo SAA antibody
20R-1792	Fitzgerald	100 ug	EUR 673
Description: Rabbit polyclonal Apo SAA antibody

Recombinant Human SAA
P0209	FN Test	100ug	EUR 522.36
Formulation: pH7.4, Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose Reconstitution: Sterile distilled water Purity: Greater than 95% by SDS-PAGE gel analyses Uniprot ID: P0DJI8
Description: Recombinant Human protein for SAA

mPEG-SAA,10K
33-MF001015-10K	Biochempeg	EUR 211.00 EUR 531.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,1K
33-MF001015-1K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,20K
33-MF001015-20K	Biochempeg	EUR 211.00 EUR 531.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,2K
33-MF001015-2K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,30K
33-MF001015-30K	Biochempeg	EUR 211.00 EUR 531.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,4K
33-MF001015-4K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,5K
33-MF001015-5K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Apo-SAA, human recombinant
4324-10	Biovision		EUR 137

Apo-SAA, human recombinant
4324-1000	Biovision		EUR 920

Apo-SAA, human recombinant
4324-50	Biovision		EUR 256

Apo-SAA, human recombinant
4324-500	Biovision		EUR 756

Cat SAA ELISA Kit
E-20SAA	Immunology Consultants Laboratory	1 x 96 well plate	EUR 461

Chicken SAA ELISA Kit
E-30SAA	Immunology Consultants Laboratory	1 x 96 well plate	EUR 492

Dog SAA ELISA Kit
E-40SAA	Immunology Consultants Laboratory	1 x 96 well plate	EUR 461

Horse SAA ELISA Kit
E-70SAA	Immunology Consultants Laboratory	1 x 96 well plate	EUR 517

Human SAA ELISA Kit
E-80SAA	Immunology Consultants Laboratory	1 x 96 well plate	EUR 461

Mouse SAA ELISA Kit
E-90SAA	Immunology Consultants Laboratory	1 x 96 well plate	EUR 395

Human SAA ELISA Kit
DEIA450	Creative Diagnostics	96T	EUR 1060
Description: ThisHuman SAA ELISA Kit is to be used for the in vitro quantitative determinationof human serum amyloid A (SAA) concentrations in serum, plasma, cell culture supernatant, and other biological fluids.

4-Arm PEG-SAA
abx085101-10kDa1g	Abbexa	10 kDa; 1 g	EUR 384
Shipped within 5-10 working days.

4-Arm PEG-SAA
abx085101-10kDa5g	Abbexa	10 kDa; 5 g	EUR 634
Shipped within 5-10 working days.

4-Arm PEG-SAA
abx085101-20kDa5g	Abbexa	20 kDa; 5 g	EUR 634
Shipped within 5-10 working days.

4-Arm PEG-SAA
abx085101-2kDa1g	Abbexa	2 kDa; 1 g	EUR 356
Shipped within 5-10 working days.

8-Arm PEG-SAA
abx085112-10kDa1g	Abbexa	10 kDa; 1 g	EUR 328
Shipped within 5-10 working days.

8-Arm PEG-SAA
abx085112-10kDa5g	Abbexa	10 kDa; 5 g	EUR 620
Shipped within 5-10 working days.

8-Arm PEG-SAA
abx085112-20kDa5g	Abbexa	20 kDa; 5 g	EUR 620
Shipped within 5-10 working days.

8-Arm PEG-SAA
abx085112-40kDa1g	Abbexa	40 kDa; 1 g	EUR 356
Shipped within 5-10 working days.

Human SAA ELISA Kit
EHS0235	Abclonal	96Tests	EUR 521

Bovine SAA ELISA Kit
EBS0235	Abclonal	96Tests	EUR 521

Anserini SAA ELISA Kit
EAS0235	Abclonal	96Tests	EUR 521

Chicken SAA ELISA Kit
ECKS0235	Abclonal	96Tests	EUR 521

Canine SAA ELISA Kit
ECS0235	Abclonal	96Tests	EUR 521

SAA ELISA KIT|Human
EF000259	Lifescience Market	96 Tests	EUR 689

Goat SAA ELISA Kit
EGTS0235	Abclonal	96Tests	EUR 521

4-ArmPEG-SAA,10K
33-A44015-10K	Biochempeg	EUR 174.00 EUR 420.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-ArmPEG-SAA,20K
33-A44015-20K	Biochempeg	EUR 174.00 EUR 420.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-ArmPEG-SAA,2K
33-A44015-2K	Biochempeg	EUR 198.00 EUR 494.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,10K
33-A88015-10K	Biochempeg	EUR 149.00 EUR 346.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,20K
33-A88015-20K	Biochempeg	EUR 149.00 EUR 346.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,40K
33-A88015-40K	Biochempeg	EUR 174.00 EUR 420.00	1g 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Porcine SAA ELISA Kit
EPS0235	Abclonal	96Tests	EUR 521

Sheep SAA ELISA Kit
ESS0235	Abclonal	96Tests	EUR 521

Rat SAA ELISA Kit
ERS0235	Abclonal	96Tests	EUR 521

Rabbit SAA ELISA Kit
ERTS0235	Abclonal	96Tests	EUR 521

Monkey SAA ELISA Kit
EMKS0235	Abclonal	96Tests	EUR 521

Mouse SAA ELISA Kit
EMS0235	Abclonal	96Tests	EUR 521

Serum Amyloid A (SAA) Antibody
48336-100ul	SAB	100ul	EUR 333

Serum Amyloid A (SAA) Antibody
48336-50ul	SAB	50ul	EUR 239

Serum Amyloid A (SAA) Antibody
abx022449-1mg	Abbexa	1 mg	EUR 1017
Shipped within 5-10 working days.

Serum Amyloid A (SAA) Antibody
abx022450-1mg	Abbexa	1 mg	EUR 1017
Shipped within 5-10 working days.

Exosomes have also been studied as delivery vehicles to transport drugs, proteins, and microRNAs of choice for therapeutic purposes. K-Ras pathway proteins have been implicated in exosome biogenesis and extravasation processes. This review provides an update on the current knowledge related to K-Ras signaling and exosomes and also discusses how these tiny vesicles can be harnessed to successfully deliver the K-Ras silencing moieties.