Ras gene (HRAS, NRAS, and KRAS) has been observed to be mutated and hyper-activated in a significant proportion of cancers. However, mutant Ras remains a challenging therapeutic target. Similarly, inhibition of targets upstream and downstream of Ras has shown limited clinical utility.
There have been attempts to develop and deliver mutant K-Ras silencing RNAs either through their encapsulation in liposomes or nanoparticles. However, these approaches show very limited success due to the lack of stability of such carrier molecules alongside associated toxicity.
There is a pressing need for the identification of better therapeutic targets for Ras or its associated pathways as well as improvements in the design of superior RNAi delivery systems to suppress mutant K-Ras. More than a decade ago, it was shown that aggregates of palmitoylated Ras isoforms (H-Ras and N-Ras) passage through the cytosol on rapidly moving nanosized particles (“rasosomes”). Fast forward a decade, considerable new knowledge has emerged in the area of small vesicles, microparticles, and exosomes. Exosomes are tiny vesicles and play a significant role in regulating cancer-related signaling pathways.
Mouse Serum Amyloid A (SAA) ELISA Kit |
RD-SAA-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 489 |
Mouse Serum Amyloid A (SAA) ELISA Kit |
RD-SAA-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 677 |
Rabbit Serum Amyloid A (SAA) ELISA Kit |
RD-SAA-Rb-48Tests |
Reddot Biotech |
48 Tests |
EUR 511 |
Rabbit Serum Amyloid A (SAA) ELISA Kit |
RD-SAA-Rb-96Tests |
Reddot Biotech |
96 Tests |
EUR 709 |
Bovine Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-b-48T |
DL Develop |
48T |
EUR 547 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids. |
Bovine Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-b-96T |
DL Develop |
96T |
EUR 715 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids. |
Human Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-Hu-48T |
DL Develop |
48T |
EUR 479 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Human Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-Hu-96T |
DL Develop |
96T |
EUR 621 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-Mu-48T |
DL Develop |
48T |
EUR 489 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-Mu-96T |
DL Develop |
96T |
EUR 635 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rabbit Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-Rb-48T |
DL Develop |
48T |
EUR 508 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rabbit Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-Rb-96T |
DL Develop |
96T |
EUR 661 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Bovine Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-b-48Tests |
Reddot Biotech |
48 Tests |
EUR 580 |
Bovine Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-b-96Tests |
Reddot Biotech |
96 Tests |
EUR 807 |
Human Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 500 |
Human Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 692 |
Mouse Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 511 |
Mouse Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 709 |
Rabbit Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-Rb-48Tests |
Reddot Biotech |
48 Tests |
EUR 534 |
Rabbit Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-Rb-96Tests |
Reddot Biotech |
96 Tests |
EUR 742 |
TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 10 tests/pack |
SAA-RDT-10 |
Alpha Diagnostics |
1 pack |
EUR 171 |
TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 25 tests/pack |
SAA-RDT-25 |
Alpha Diagnostics |
1 pack |
EUR 293 |
SAA-PEG-SAA |
abx085047-20kDa1g |
Abbexa |
20 kDa; 1 g |
EUR 453 |
|
SAA-PEG-SAA |
abx085047-2kDa1g |
Abbexa |
2 kDa; 1 g |
EUR 453 |
|
SAA-PEG-SAA |
abx085047-10kDa1g |
Abbexa |
10 kDa; 1 g |
EUR 453 |
|
SAA-PEG-SAA |
abx085047-1kDa1g |
Abbexa |
1 kDa; 1 g |
EUR 453 |
|
SAA-PEG-SAA,10K |
33-HO015015-10K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SAA-PEG-SAA,1K |
33-HO015015-1K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SAA-PEG-SAA,20K |
33-HO015015-20K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SAA-PEG-SAA,2K |
33-HO015015-2K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SAA-PEG-SAA,3.4K |
33-HO015015-3.4K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SAA-PEG-SAA,5K |
33-HO015015-5K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
TESTO (Testosterone) ELISA test |
19 |
Biobase |
96T/Box |
Ask for price |
|
Description: ELISA based test for quantitative detection of O (osterone) |
SAA Protein |
abx060299-100ug |
Abbexa |
100 ug |
EUR 829 |
|
mPEG-SAA |
abx085023-10kDa1g |
Abbexa |
10 kDa; 1 g |
EUR 370 |
|
mPEG-SAA |
abx085023-1kDa1g |
Abbexa |
1 kDa; 1 g |
EUR 356 |
|
mPEG-SAA |
abx085023-20kDa1g |
Abbexa |
20 kDa; 1 g |
EUR 370 |
|
mPEG-SAA |
abx085023-2kDa1g |
Abbexa |
2 kDa; 1 g |
EUR 356 |
|
mPEG-SAA |
abx085023-5kDa1g |
Abbexa |
5 kDa; 1 g |
EUR 356 |
|
SAA antibody |
10-7959 |
Fitzgerald |
500 ug |
EUR 349 |
Description: Mouse monoclonal SAA antibody |
SAA antibody |
10-7960 |
Fitzgerald |
500 ug |
EUR 349 |
Description: Mouse monoclonal SAA antibody |
SAA antibody |
10R-10351 |
Fitzgerald |
100 ug |
EUR 435 |
Description: Mouse monoclonal SAA antibody |
SAA antibody |
20-1715 |
Fitzgerald |
1 ml |
EUR 138 |
Description: Goat polyclonal SAA antibody |
mPEG-SAA,10K |
33-MF001015-10K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-SAA,1K |
33-MF001015-1K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-SAA,20K |
33-MF001015-20K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-SAA,2K |
33-MF001015-2K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-SAA,30K |
33-MF001015-30K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-SAA,4K |
33-MF001015-4K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-SAA,5K |
33-MF001015-5K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
Recombinant Human SAA |
P0209 |
FN Test |
100ug |
EUR 522.36 |
|
Description: Recombinant Human protein for SAA |
Apo SAA antibody |
20R-1792 |
Fitzgerald |
100 ug |
EUR 673 |
Description: Rabbit polyclonal Apo SAA antibody |
Sheep SAA ELISA Kit |
ESS0235 |
Abclonal |
96Tests |
EUR 521 |
Human SAA ELISA Kit |
DEIA450 |
Creative Diagnostics |
96T |
EUR 1060 |
Description: ThisHuman SAA ELISA Kit is to be used for the in vitro quantitative determinationof human serum amyloid A (SAA) concentrations in serum, plasma, cell culture supernatant, and other biological fluids. |
Rat SAA ELISA Kit |
ERS0235 |
Abclonal |
96Tests |
EUR 521 |
Rabbit SAA ELISA Kit |
ERTS0235 |
Abclonal |
96Tests |
EUR 521 |
Monkey SAA ELISA Kit |
EMKS0235 |
Abclonal |
96Tests |
EUR 521 |
Mouse SAA ELISA Kit |
EMS0235 |
Abclonal |
96Tests |
EUR 521 |
Porcine SAA ELISA Kit |
EPS0235 |
Abclonal |
96Tests |
EUR 521 |
Goat SAA ELISA Kit |
EGTS0235 |
Abclonal |
96Tests |
EUR 521 |
Human SAA ELISA Kit |
EHS0235 |
Abclonal |
96Tests |
EUR 521 |
Bovine SAA ELISA Kit |
EBS0235 |
Abclonal |
96Tests |
EUR 521 |
Chicken SAA ELISA Kit |
ECKS0235 |
Abclonal |
96Tests |
EUR 521 |
Canine SAA ELISA Kit |
ECS0235 |
Abclonal |
96Tests |
EUR 521 |
Anserini SAA ELISA Kit |
EAS0235 |
Abclonal |
96Tests |
EUR 521 |
4-ArmPEG-SAA,10K |
33-A44015-10K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
4-ArmPEG-SAA,20K |
33-A44015-20K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
4-ArmPEG-SAA,2K |
33-A44015-2K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
8-ArmPEG-SAA,10K |
33-A88015-10K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
8-ArmPEG-SAA,20K |
33-A88015-20K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
8-ArmPEG-SAA,40K |
33-A88015-40K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
4-Arm PEG-SAA |
abx085101-10kDa1g |
Abbexa |
10 kDa; 1 g |
EUR 384 |
|
4-Arm PEG-SAA |
abx085101-10kDa5g |
Abbexa |
10 kDa; 5 g |
EUR 634 |
|
4-Arm PEG-SAA |
abx085101-20kDa5g |
Abbexa |
20 kDa; 5 g |
EUR 634 |
|
4-Arm PEG-SAA |
abx085101-2kDa1g |
Abbexa |
2 kDa; 1 g |
EUR 356 |
|
8-Arm PEG-SAA |
abx085112-10kDa1g |
Abbexa |
10 kDa; 1 g |
EUR 328 |
|
8-Arm PEG-SAA |
abx085112-10kDa5g |
Abbexa |
10 kDa; 5 g |
EUR 620 |
|
8-Arm PEG-SAA |
abx085112-20kDa5g |
Abbexa |
20 kDa; 5 g |
EUR 620 |
|
8-Arm PEG-SAA |
abx085112-40kDa1g |
Abbexa |
40 kDa; 1 g |
EUR 356 |
|
Apo-SAA, human recombinant |
4324-10 |
Biovision |
|
EUR 137 |
Apo-SAA, human recombinant |
4324-1000 |
Biovision |
|
EUR 920 |
Apo-SAA, human recombinant |
4324-50 |
Biovision |
|
EUR 256 |
Apo-SAA, human recombinant |
4324-500 |
Biovision |
|
EUR 756 |
Apo-SAA Recombinant Protein |
40-129-001mg |
ProSci |
0.01 mg |
EUR 259.25 |
Description: Human apo-SAA is a 104 amino acid polypeptide that circulates primarily in association with high-density lipoproteins (HDL). The level of apo-SAA, normally 1-5 µg/mL in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apo-lipoprotein. The human SAA gene codes for a 122 amino acid polypeptide, which contains an 18 amino acid N-terminal signal sequence. Recombinant Apo-SAA is a consensus SAA molecule corresponding to human apo-SAA1alpha except for the presence of an N-terminal methionine and substitution of asparagine for aspartic acid at position 60 and arginine for histidine at position 71(the later two substituted residues are present in apo-SAA2beta). |
Apo-SAA Recombinant Protein |
40-129-005mg |
ProSci |
0.05 mg |
EUR 364.25 |
Description: Human apo-SAA is a 104 amino acid polypeptide that circulates primarily in association with high-density lipoproteins (HDL). The level of apo-SAA, normally 1-5 µg/mL in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apo-lipoprotein. The human SAA gene codes for a 122 amino acid polypeptide, which contains an 18 amino acid N-terminal signal sequence. Recombinant Apo-SAA is a consensus SAA molecule corresponding to human apo-SAA1alpha except for the presence of an N-terminal methionine and substitution of asparagine for aspartic acid at position 60 and arginine for histidine at position 71(the later two substituted residues are present in apo-SAA2beta). |
Anti-Trimethyl-Histone H3 (Lys79) Rabbit Monoclonal Antibody, Clone#RM157 |
M06819-19 |
BosterBio |
100ug |
EUR 468 |
Description: Anti-Trimethyl-Histone H3 (Lys79) Rabbit Monoclonal Antibody, Clone#RM157 tested in WB, ELISA, Multiplex, reactive to All Vertebrates |
PEDF, Pigment Epithelium-derived Factor, human |
RC213-19 |
Bio Basic |
5ug |
EUR 104.38 |
|
Exosomes have also been studied as delivery vehicles to transport drugs, proteins, and microRNAs of choice for therapeutic purposes. K-Ras pathway proteins have been implicated in exosome biogenesis and extravasation processes. This review provides an update on the current knowledge related to K-Ras signaling and exosomes and also discusses how these tiny vesicles can be harnessed to successfully deliver the K-Ras silencing moieties.