Ras and exosome signaling.

Ras gene (HRAS, NRAS, and KRAS) has been observed to be mutated and hyper-activated in a significant proportion of cancers. However, mutant Ras remains a challenging therapeutic target. Similarly, inhibition of targets upstream and downstream of Ras has shown limited clinical utility.

There have been attempts to develop and deliver mutant K-Ras silencing RNAs either through their encapsulation in liposomes or nanoparticles. However, these approaches show very limited success due to the lack of stability of such carrier molecules alongside associated toxicity.

There is a pressing need for the identification of better therapeutic targets for Ras or its associated pathways as well as improvements in the design of superior RNAi delivery systems to suppress mutant K-Ras. More than a decade ago, it was shown that aggregates of palmitoylated Ras isoforms (H-Ras and N-Ras) passage through the cytosol on rapidly moving nanosized particles (“rasosomes”). Fast forward a decade, considerable new knowledge has emerged in the area of small vesicles, microparticles, and exosomes. Exosomes are tiny vesicles and play a significant role in regulating cancer-related signaling pathways.

Mouse Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Mu-48Tests 48 Tests
EUR 489

Mouse Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Mu-96Tests 96 Tests
EUR 677

Rabbit Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Rb-48Tests 48 Tests
EUR 511

Rabbit Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Rb-96Tests 96 Tests
EUR 709

Bovine Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-b-48T 48T
EUR 547
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids.

Bovine Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-b-96T 96T
EUR 715
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids.

Human Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Hu-48T 48T
EUR 479
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Hu-96T 96T
EUR 621
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Mu-48T 48T
EUR 489
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Mu-96T 96T
EUR 635
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Rb-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Rb-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-b-48Tests 48 Tests
EUR 580

Bovine Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-b-96Tests 96 Tests
EUR 807

Human Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Hu-48Tests 48 Tests
EUR 500

Human Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Hu-96Tests 96 Tests
EUR 692

Mouse Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Mu-48Tests 48 Tests
EUR 511

Mouse Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Mu-96Tests 96 Tests
EUR 709

Rabbit Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Rb-48Tests 48 Tests
EUR 534

Rabbit Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Rb-96Tests 96 Tests
EUR 742

TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 10 tests/pack

SAA-RDT-10 1 pack
EUR 171

TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 25 tests/pack

SAA-RDT-25 1 pack
EUR 293

SAA-PEG-SAA

abx085047-20kDa1g 20 kDa; 1 g
EUR 453

SAA-PEG-SAA

abx085047-2kDa1g 2 kDa; 1 g
EUR 453

SAA-PEG-SAA

abx085047-10kDa1g 10 kDa; 1 g
EUR 453

SAA-PEG-SAA

abx085047-1kDa1g 1 kDa; 1 g
EUR 453

SAA-PEG-SAA,10K

33-HO015015-10K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,1K

33-HO015015-1K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,20K

33-HO015015-20K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,2K

33-HO015015-2K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,3.4K

33-HO015015-3.4K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,5K

33-HO015015-5K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA

E64C01201 20ug
EUR 382

TESTO (Testosterone) ELISA test

19 96T/Box Ask for price
Description: ELISA based test for quantitative detection of O (osterone)

SAA Protein

abx060299-100ug 100 ug
EUR 829

mPEG-SAA

abx085023-10kDa1g 10 kDa; 1 g
EUR 370

mPEG-SAA

abx085023-1kDa1g 1 kDa; 1 g
EUR 356

mPEG-SAA

abx085023-20kDa1g 20 kDa; 1 g
EUR 370

mPEG-SAA

abx085023-2kDa1g 2 kDa; 1 g
EUR 356

mPEG-SAA

abx085023-5kDa1g 5 kDa; 1 g
EUR 356

Bovine(SAA)

QY-E60061 96T
EUR 426

SAA antibody

10-7959 500 ug
EUR 349
Description: Mouse monoclonal SAA antibody

SAA antibody

10-7960 500 ug
EUR 349
Description: Mouse monoclonal SAA antibody

SAA antibody

10R-10351 100 ug
EUR 435
Description: Mouse monoclonal SAA antibody

SAA antibody

20-1715 1 ml
EUR 138
Description: Goat polyclonal SAA antibody

mPEG-SAA,10K

33-MF001015-10K
  • EUR 211.00
  • EUR 531.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,1K

33-MF001015-1K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,20K

33-MF001015-20K
  • EUR 211.00
  • EUR 531.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,2K

33-MF001015-2K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,30K

33-MF001015-30K
  • EUR 211.00
  • EUR 531.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,4K

33-MF001015-4K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,5K

33-MF001015-5K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Recombinant Human SAA

P0209 100ug
EUR 522.36
Description: Recombinant Human protein for SAA

Apo SAA antibody

20R-1792 100 ug
EUR 673
Description: Rabbit polyclonal Apo SAA antibody

Sheep SAA ELISA Kit

ESS0235 96Tests
EUR 521

Human SAA ELISA Kit

DEIA450 96T
EUR 1060
Description: ThisHuman SAA ELISA Kit is to be used for the in vitro quantitative determinationof human serum amyloid A (SAA) concentrations in serum, plasma, cell culture supernatant, and other biological fluids.

Rat SAA ELISA Kit

ERS0235 96Tests
EUR 521

Rabbit SAA ELISA Kit

ERTS0235 96Tests
EUR 521

Monkey SAA ELISA Kit

EMKS0235 96Tests
EUR 521

Mouse SAA ELISA Kit

EMS0235 96Tests
EUR 521

Porcine SAA ELISA Kit

EPS0235 96Tests
EUR 521

Goat SAA ELISA Kit

EGTS0235 96Tests
EUR 521

Human SAA ELISA Kit

EHS0235 96Tests
EUR 521

Bovine SAA ELISA Kit

EBS0235 96Tests
EUR 521

Chicken SAA ELISA Kit

ECKS0235 96Tests
EUR 521

Canine SAA ELISA Kit

ECS0235 96Tests
EUR 521

Anserini SAA ELISA Kit

EAS0235 96Tests
EUR 521

4-ArmPEG-SAA,10K

33-A44015-10K
  • EUR 174.00
  • EUR 420.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-ArmPEG-SAA,20K

33-A44015-20K
  • EUR 174.00
  • EUR 420.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-ArmPEG-SAA,2K

33-A44015-2K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,10K

33-A88015-10K
  • EUR 149.00
  • EUR 346.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,20K

33-A88015-20K
  • EUR 149.00
  • EUR 346.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,40K

33-A88015-40K
  • EUR 174.00
  • EUR 420.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-Arm PEG-SAA

abx085101-10kDa1g 10 kDa; 1 g
EUR 384

4-Arm PEG-SAA

abx085101-10kDa5g 10 kDa; 5 g
EUR 634

4-Arm PEG-SAA

abx085101-20kDa5g 20 kDa; 5 g
EUR 634

4-Arm PEG-SAA

abx085101-2kDa1g 2 kDa; 1 g
EUR 356

8-Arm PEG-SAA

abx085112-10kDa1g 10 kDa; 1 g
EUR 328

8-Arm PEG-SAA

abx085112-10kDa5g 10 kDa; 5 g
EUR 620

8-Arm PEG-SAA

abx085112-20kDa5g 20 kDa; 5 g
EUR 620

8-Arm PEG-SAA

abx085112-40kDa1g 40 kDa; 1 g
EUR 356

SAA ELISA KIT|Human

EF000259 96 Tests
EUR 689

Apo-SAA, human recombinant

4324-10
EUR 137

Apo-SAA, human recombinant

4324-1000
EUR 920

Apo-SAA, human recombinant

4324-50
EUR 256

Apo-SAA, human recombinant

4324-500
EUR 756

Cat SAA ELISA Kit

E-20SAA 1 x 96 well plate
EUR 461

Chicken SAA ELISA Kit

E-30SAA 1 x 96 well plate
EUR 492

Dog SAA ELISA Kit

E-40SAA 1 x 96 well plate
EUR 461

Horse SAA ELISA Kit

E-70SAA 1 x 96 well plate
EUR 517

Human SAA ELISA Kit

E-80SAA 1 x 96 well plate
EUR 461

Mouse SAA ELISA Kit

E-90SAA 1 x 96 well plate
EUR 395

Apo-SAA Recombinant Protein

40-129-001mg 0.01 mg
EUR 259.25
Description: Human apo-SAA is a 104 amino acid polypeptide that circulates primarily in association with high-density lipoproteins (HDL). The level of apo-SAA, normally 1-5 µg/mL in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apo-lipoprotein. The human SAA gene codes for a 122 amino acid polypeptide, which contains an 18 amino acid N-terminal signal sequence. Recombinant Apo-SAA is a consensus SAA molecule corresponding to human apo-SAA1alpha except for the presence of an N-terminal methionine and substitution of asparagine for aspartic acid at position 60 and arginine for histidine at position 71(the later two substituted residues are present in apo-SAA2beta).

Apo-SAA Recombinant Protein

40-129-005mg 0.05 mg
EUR 364.25
Description: Human apo-SAA is a 104 amino acid polypeptide that circulates primarily in association with high-density lipoproteins (HDL). The level of apo-SAA, normally 1-5 µg/mL in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apo-lipoprotein. The human SAA gene codes for a 122 amino acid polypeptide, which contains an 18 amino acid N-terminal signal sequence. Recombinant Apo-SAA is a consensus SAA molecule corresponding to human apo-SAA1alpha except for the presence of an N-terminal methionine and substitution of asparagine for aspartic acid at position 60 and arginine for histidine at position 71(the later two substituted residues are present in apo-SAA2beta).

Anti-Trimethyl-Histone H3 (Lys79) Rabbit Monoclonal Antibody, Clone#RM157

M06819-19 100ug
EUR 468
Description: Anti-Trimethyl-Histone H3 (Lys79) Rabbit Monoclonal Antibody, Clone#RM157 tested in WB, ELISA, Multiplex, reactive to All Vertebrates

PEDF, Pigment Epithelium-derived Factor, human

RC213-19 5ug
EUR 104.38

Exosomes have also been studied as delivery vehicles to transport drugs, proteins, and microRNAs of choice for therapeutic purposes. K-Ras pathway proteins have been implicated in exosome biogenesis and extravasation processes. This review provides an update on the current knowledge related to K-Ras signaling and exosomes and also discusses how these tiny vesicles can be harnessed to successfully deliver the K-Ras silencing moieties.