Main constraints for RNAi induced by expressed long dsRNA in mouse cells.

RNAi is the sequence-specific mRNA degradation guided by siRNAs produced from long dsRNA by RNase Dicer. Proteins executing RNAi are present in mammalian cells but rather sustain the microRNA pathway.

Aiming for a systematic analysis of mammalian RNAi, we report here that the main bottleneck for RNAi efficiency is the production of functional siRNAs, which integrates Dicer activity, dsRNA structure, and siRNA targeting efficiency. Unexpectedly, increased expression of Dicer cofactors TARBP2 or PACT reduces RNAi but not microRNA function.

Elimination of protein kinase R, a key dsRNA sensor in the interferon response, had minimal positive effects on RNAi activity in fibroblasts. Without high Dicer activity, RNAi can still occur when the initial Dicer cleavage of the substrate yields an efficient siRNA.

9998 SCREW CAP 415/18

9998-18 192/pk
EUR 103.00
Description: General Apparatus; Stoppers

COVER GLASS, NO. 1, SQUARE 18 X 18MM

2845-18 100/pk
EUR 112.00
Description: Cover Glass; Cover Glass, CGW

COVER GLASS, NO. 2, SQUARE 18 X 18MM

2855-18 50/pk
EUR 83.00
Description: Cover Glass; Cover Glass, CGW

Bovine Serum Amyloid A (SAA) ELISA Kit

DL-SAA-b-192 1 kit of 192 tests
EUR 1231.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Bovine Serum Amyloid A (SAA)

Bovine Serum Amyloid A (SAA) ELISA Kit

DL-SAA-b-48 1 kit of 48 tests
EUR 510.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Bovine Serum Amyloid A (SAA)

Bovine Serum Amyloid A (SAA) ELISA Kit

DL-SAA-b-96 1 kit of 96 tests
EUR 685.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Bovine Serum Amyloid A (SAA)

Human Serum Amyloid A (SAA) ELISA Kit

DL-SAA-Hu-192 1 kit of 192 tests
EUR 1054.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Human Serum Amyloid A (SAA)

Human Serum Amyloid A (SAA) ELISA Kit

DL-SAA-Hu-48 1 kit of 48 tests
EUR 447.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Human Serum Amyloid A (SAA)

Human Serum Amyloid A (SAA) ELISA Kit

DL-SAA-Hu-96 1 kit of 96 tests
EUR 597.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Human Serum Amyloid A (SAA)

Mouse Serum Amyloid A (SAA) ELISA Kit

DL-SAA-Mu-192 1 kit of 192 tests
EUR 1079.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Mouse Serum Amyloid A (SAA)

Mouse Serum Amyloid A (SAA) ELISA Kit

DL-SAA-Mu-48 1 kit of 48 tests
EUR 456.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Mouse Serum Amyloid A (SAA)

Mouse Serum Amyloid A (SAA) ELISA Kit

DL-SAA-Mu-96 1 kit of 96 tests
EUR 609.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Mouse Serum Amyloid A (SAA)

Rabbit Serum Amyloid A (SAA) ELISA Kit

DL-SAA-Rb-192 1 kit of 192 tests
EUR 1130.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Rabbit Serum Amyloid A (SAA)

Rabbit Serum Amyloid A (SAA) ELISA Kit

DL-SAA-Rb-48 1 kit of 48 tests
EUR 474.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Rabbit Serum Amyloid A (SAA)

Rabbit Serum Amyloid A (SAA) ELISA Kit

DL-SAA-Rb-96 1 kit of 96 tests
EUR 635.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Rabbit Serum Amyloid A (SAA)

Bovine Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-b-48T 48T
EUR 547.00
  • Should the Bovine Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids.

Bovine Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-b-96T 96T
EUR 715.00
  • Should the Bovine Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids.

Human Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Hu-48T 48T
EUR 479.00
  • Should the Human Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Hu-96T 96T
EUR 621.00
  • Should the Human Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Mu-48T 48T
EUR 489.00
  • Should the Mouse Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Mu-96T 96T
EUR 635.00
  • Should the Mouse Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Rb-48T 48T
EUR 508.00
  • Should the Rabbit Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Serum Amyloid A (SAA) ELISA Kit

DLR-SAA-Rb-96T 96T
EUR 661.00
  • Should the Rabbit Serum Amyloid A (SAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Serum Amyloid A (SAA) ELISA Kit

RD-SAA-b-48Tests 48 Tests
EUR 555.00

Bovine Serum Amyloid A (SAA) ELISA Kit

RD-SAA-b-96Tests 96 Tests
EUR 771.00

Human Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Hu-48Tests 48 Tests
EUR 478.00

Human Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Hu-96Tests 96 Tests
EUR 662.00

Mouse Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Mu-48Tests 48 Tests
EUR 489.00

Mouse Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Mu-96Tests 96 Tests
EUR 677.00

Rabbit Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Rb-48Tests 48 Tests
EUR 511.00

Rabbit Serum Amyloid A (SAA) ELISA Kit

RD-SAA-Rb-96Tests 96 Tests
EUR 709.00

Bovine Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-b-48Tests 48 Tests
EUR 580.00

Bovine Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-b-96Tests 96 Tests
EUR 807.00

Human Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Hu-48Tests 48 Tests
EUR 500.00

Human Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Hu-96Tests 96 Tests
EUR 692.00

Mouse Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Mu-48Tests 48 Tests
EUR 511.00

Mouse Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Mu-96Tests 96 Tests
EUR 709.00

Rabbit Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Rb-48Tests 48 Tests
EUR 534.00

Rabbit Serum Amyloid A (SAA) ELISA Kit

RDR-SAA-Rb-96Tests 96 Tests
EUR 742.00

COVER GLASS, NO. 1 1/2, SQUARE 18 X 18MM

2850-18 100/pk
EUR 131.00
Description: Cover Glass; Cover Glass, CGW

TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 10 tests/pack

SAA-RDT-10 1 pack
EUR 171.00

TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 25 tests/pack

SAA-RDT-25 1 pack
EUR 293.00

SAA-PEG-SAA

abx085047-10kDa1g 10 kDa; 1 g
EUR 453.00
  • Shipped within 5-10 working days.

SAA-PEG-SAA

abx085047-1kDa1g 1 kDa; 1 g
EUR 453.00
  • Shipped within 5-10 working days.

SAA-PEG-SAA

abx085047-20kDa1g 20 kDa; 1 g
EUR 453.00
  • Shipped within 5-10 working days.

SAA-PEG-SAA

abx085047-2kDa1g 2 kDa; 1 g
EUR 453.00
  • Shipped within 5-10 working days.

SAA-PEG-SAA,10K

33-HO015015-10K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,1K

33-HO015015-1K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,20K

33-HO015015-20K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,2K

33-HO015015-2K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,3.4K

33-HO015015-3.4K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA-PEG-SAA,5K

33-HO015015-5K
  • EUR 259.00
  • EUR 677.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

SAA

E64C01201 20ug
EUR 382.00

FT4 (Free thyroxine) ELISA test

18 96T/Box Ask for price
  • Area of application: Hormone testing
Description: ELISA based test for quantitative detection of FT4 (Free thyroxine)

SAA antibody

10-7959 500 ug
EUR 349.00
Description: Mouse monoclonal SAA antibody

SAA antibody

10-7960 500 ug
EUR 349.00
Description: Mouse monoclonal SAA antibody

SAA antibody

10R-10351 100 ug
EUR 435.00
Description: Mouse monoclonal SAA antibody

SAA Protein

abx060299-100ug 100 ug
EUR 829.00
  • Shipped within 5-10 working days.

SAA antibody

20-1715 1 ml
EUR 138.00
Description: Goat polyclonal SAA antibody

mPEG-SAA

abx085023-10kDa1g 10 kDa; 1 g
EUR 370.00
  • Shipped within 5-10 working days.

mPEG-SAA

abx085023-1kDa1g 1 kDa; 1 g
EUR 356.00
  • Shipped within 5-10 working days.

mPEG-SAA

abx085023-20kDa1g 20 kDa; 1 g
EUR 370.00
  • Shipped within 5-10 working days.

mPEG-SAA

abx085023-2kDa1g 2 kDa; 1 g
EUR 356.00
  • Shipped within 5-10 working days.

mPEG-SAA

abx085023-5kDa1g 5 kDa; 1 g
EUR 356.00
  • Shipped within 5-10 working days.

Bovine(SAA)

QY-E60061 96T
EUR 426.00

Apo SAA antibody

20R-1792 100 ug
EUR 673.00
Description: Rabbit polyclonal Apo SAA antibody

mPEG-SAA,10K

33-MF001015-10K
  • EUR 211.00
  • EUR 531.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,1K

33-MF001015-1K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,20K

33-MF001015-20K
  • EUR 211.00
  • EUR 531.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,2K

33-MF001015-2K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,30K

33-MF001015-30K
  • EUR 211.00
  • EUR 531.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,4K

33-MF001015-4K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

mPEG-SAA,5K

33-MF001015-5K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Recombinant Human SAA

P0209 100ug
EUR 522.36
  • Formulation: pH7.4, Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose
  • Reconstitution: Sterile distilled water
  • Purity: Greater than 95% by SDS-PAGE gel analyses
  • Uniprot ID: P0DJI8
Description: Recombinant Human protein for SAA

Apo-SAA, human recombinant

4324-10
EUR 137.00

Apo-SAA, human recombinant

4324-1000
EUR 920.00

Apo-SAA, human recombinant

4324-50
EUR 256.00

Apo-SAA, human recombinant

4324-500
EUR 756.00

4-ArmPEG-SAA,10K

33-A44015-10K
  • EUR 174.00
  • EUR 420.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-ArmPEG-SAA,20K

33-A44015-20K
  • EUR 174.00
  • EUR 420.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-ArmPEG-SAA,2K

33-A44015-2K
  • EUR 198.00
  • EUR 494.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,10K

33-A88015-10K
  • EUR 149.00
  • EUR 346.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,20K

33-A88015-20K
  • EUR 149.00
  • EUR 346.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

8-ArmPEG-SAA,40K

33-A88015-40K
  • EUR 174.00
  • EUR 420.00
  • 1g
  • 5g
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4-Arm PEG-SAA

abx085101-10kDa1g 10 kDa; 1 g
EUR 384.00
  • Shipped within 5-10 working days.

4-Arm PEG-SAA

abx085101-10kDa5g 10 kDa; 5 g
EUR 634.00
  • Shipped within 5-10 working days.

4-Arm PEG-SAA

abx085101-20kDa5g 20 kDa; 5 g
EUR 634.00
  • Shipped within 5-10 working days.

4-Arm PEG-SAA

abx085101-2kDa1g 2 kDa; 1 g
EUR 356.00
  • Shipped within 5-10 working days.

8-Arm PEG-SAA

abx085112-10kDa1g 10 kDa; 1 g
EUR 328.00
  • Shipped within 5-10 working days.

8-Arm PEG-SAA

abx085112-10kDa5g 10 kDa; 5 g
EUR 620.00
  • Shipped within 5-10 working days.

8-Arm PEG-SAA

abx085112-20kDa5g 20 kDa; 5 g
EUR 620.00
  • Shipped within 5-10 working days.

8-Arm PEG-SAA

abx085112-40kDa1g 40 kDa; 1 g
EUR 356.00
  • Shipped within 5-10 working days.

Cat SAA ELISA Kit

E-20SAA 1 x 96 well plate
EUR 461.00

Chicken SAA ELISA Kit

E-30SAA 1 x 96 well plate
EUR 492.00

Dog SAA ELISA Kit

E-40SAA 1 x 96 well plate
EUR 461.00

Horse SAA ELISA Kit

E-70SAA 1 x 96 well plate
EUR 517.00

Human SAA ELISA Kit

E-80SAA 1 x 96 well plate
EUR 461.00

Mouse SAA ELISA Kit

E-90SAA 1 x 96 well plate
EUR 395.00

SAA ELISA KIT|Human

EF000259 96 Tests
EUR 689.00

Porcine SAA ELISA Kit

EPS0235 96Tests
EUR 521.00

Sheep SAA ELISA Kit

ESS0235 96Tests
EUR 521.00

Anserini SAA ELISA Kit

EAS0235 96Tests
EUR 521.00

Bovine SAA ELISA Kit

EBS0235 96Tests
EUR 521.00

Human SAA ELISA Kit

EHS0235 96Tests
EUR 521.00

Human SAA ELISA Kit

DEIA450 96T
EUR 1060.00
Description: ThisHuman SAA ELISA Kit is to be used for the in vitro quantitative determinationof human serum amyloid A (SAA) concentrations in serum, plasma, cell culture supernatant, and other biological fluids.

Goat SAA ELISA Kit

EGTS0235 96Tests
EUR 521.00

Canine SAA ELISA Kit

ECS0235 96Tests
EUR 521.00

Chicken SAA ELISA Kit

ECKS0235 96Tests
EUR 521.00

Mouse SAA ELISA Kit

EMS0235 96Tests
EUR 521.00

Rat SAA ELISA Kit

ERS0235 96Tests
EUR 521.00

Efficient mammalian RNAi may use substrates with some features of microRNA precursors, merging both pathways even more than previously suggested. Although optimized endogenous Dicer substrates mimicking miRNA features could evolve for endogenous regulations, the same principles would make antiviral RNAi inefficient as viruses would adapt to avoid efficacy.